CD8 T cell deficiency impairs control of Epstein–Barr virus and worsens with age in multiple sclerosis

REFERENCES 1. Andersen PM, Nilsson P, Keränen ML, et al. Phenotypic heterogeneity in MND-patients with CuZn-superoxide dismutase mutations in Scandinavia. Brain 1997;10:1723e37. 2. Ikeda M, Abe K, Aoki M, et al. Variable clinical symptoms in familial amyotrophic lateral sclerosis with a novel point mutation in the Cu/Zn superoxide dismutase gene. Neurology 1995;45:2038e42. 3. Meyer T, Schwan A, Dullinger JS, et al. Early-onset ALS with long-term survival associated with spastin mutation. Neurology 2005;65:141e3. 4. Mase G, Ros S, Gemma A, et al. ALS with variable phenotypes in a six-generation family caused by leu144phe mutation in the SOD1 gene. J Neurol Sci 2001;191:11e18. 5. Birve A, Neuwirth C, Weber M, et al. A novel SOD1 splice site mutation associated with familial ALS revealed by SOD activity analysis. Hum Mol Genet 2010;19:4201e6.